AFAIK, there are just two design parameters that need to change to go from gasoline to E100:

I think the most important is the compression ratio. Increasing the compression ratio has been shown to improve gas mileage of E85 vehicles. Instead of a 25% drop in fuel efficiency, they only have a 15% or so drop.

25% and 15% per gallon though.  What should we look at it we want to judge ethanol vs gasoline as a automotive fuel ... miles per Calorie or BTU?

I'd think we'd want to know the conversion efficiency from chemcial potential energy to practical kinetic energy.