You could take a look at Doctors Without Borders. They help everyone without asking questions. They studiously keep no political agenda, and never pick sides, so they can get where they are needed (that is not saying that they do not have an ideology, they are pretty lefty, but they do not wear it in their sleeves while working). They are pretty fast when responding to disasters, as they do not have any political boss to ask permission from. they are better than others at avoiding being driven by what is in the news today.

They famously said that they did not need more money for the Tsunami relief operation, that they had all they could handle, and for me that wins them kudos for honesty.

They have the resources to go where they are needed, and they already have an operation in Iran taking care of Afghan refugees, and have clinics in Mahedan.

I myself prefer to donate to the organization as a whole instead of for a specific cause. That way they can react faster and use it wherever it is more needed.