I have this running on my not particularly powerful laptop. It certainly seems a worthwhile thing to do. Just a caution, it increases boot up time and noticeably increases the time to come back from snoozing on screensaver. I can only surmise that left alone it gets stuck in to some enormous calculation and when you ask it to give you some processor time it has to crunch to a point where it can ease off. Small price to pay for helping a worthwhile project.
BOINC is part of my self-justification for purchasing a dual core Athlon.