C--
Springfield is well-served by BNSF.  There are main lines through there, not likely to be abandoned.  Good choice! (I consulted my husband, who is a railhead)
KC is uniquely positioned IMHO.  They are the BBQ capital of the world.  People will always need food and the heritage will pass on to more generations.  In addition they have a vibrant downtown that is seeing a tremendous investment currently.  In addition the rails love KC and it's jump off to the west.  While here in the STL, we may be the gateway to the west, I don't think it really starts until you hit Kansas City.
Thanks Kalpa,

I think we're leaning towards Sprinfield, MO.  We're all excited to be moving away from here (Houston, TX area).  I grew up in the Ozarks...what a beautiful place it is :)

-C.