He addresses all those arguments in his article.
A simple basic question to prove/disprove Horgan::

  • Why did we get into the mess we're in
  • and how do we get out of it?

If we can find out how to answer even just one of the two, we disprove his statement, for that would surely be the biggest discovery in the history of science.

if we can't find out, which would indicate the end or limits to science, and prove him right, then all of us here at TOD, and many others, would be better off getting drunk and fornicating without limits, and starting right now.

We would be wasting our time trying any longer. And that, in turn, would be really stupid, hence the outcome of all science to date is stupidity.

NB: I'm very sceptical about the ultimate values of science and technology, a good case can be made to argue it has had more negative than positive impact on us and our world.

But still, to say "this is all there is to know" requires that you think you're really smart. Which contradicts the stupidity. Or are we all stupid except for Horgan?

It's kind of funny that the statement implies that he is smarter than us, and we'll never be able to prove him wrong.

Wait a minute, that's religion.


And wasn't it the US Patent office that stated in the late 1800, or early 1900's that there is nothing left to patent. Because all that there is to know has been patented.  
According to this site it's an urban legend

A clue to the origin of the myth may be found in Patent Office Commissioner Henry Ellsworth's 1843 report to Congress. In it he states, "The advancement of the arts, from year to year, taxes our credulity and seems to presage the arrival of that period when human improvement must end." But Commissioner Ellsworth was simply using a bit of rhetorical flourish to emphasize the growing number of patents as presented in the rest of the report. He even outlined specific areas in which he expected patent activity to increase in the future.
Yes, thanks. That clears it up for me.
There are some pretty prominent unsolved scientific problems, including

  1. Expanding universe - how did it all begin? did it have a beginning or do the proponents of pulsating universe and steady state universes have a point?
  2. Proper scientific bridge between quantum mechanics and relativity (i.e a proper theory of everything)
  3. In biology, there is no accepted theory of speciation - formation of 2 different species (i.e. those that cannot reproduce with each other) from a common ancestor.
  4. protein folding
  5. The entire field of brain science.
  6. civilizational longevity - how to create the system to coordinate the activities of milllions of people so that humanity can survive and sustain itself - if you go totally agro, as per the permaculture guys, you are just waiting to get whacked by an asteroid strike. If you go totally techno, then you might exhaust your concentrated sources of energy.