http://r2000.chba.ca/

this has been tackled, the problem of ventilation. In fact, better to have it controlled in a highly insulated house, than the sort of uncontrolled that goes on now.

R2000 homes have been around for 25 years in Canada, and have a pretty good record. I'm not sure if there is an equivalent US standard.

AFAIK you can build one of these without requiring mechanical ventilation.

Not according to this:

R-2000 construction always includes controlled ventilation to maintain good indoor air quality. Every R-2000 home must have a mechanical ventilation system to bring fresh air in from the outside and exhaust stale air to the outside.

http://r2000.chba.ca/What_is_R2000/R2000_standard.php

Oops, missed it. Mea culpa.

http://www.passivhaus.org.uk/

also uses a mechanical system.

If you wanted to do without a mechanical system at all, and you live in a hot-cold (but dry) climate (Rocky Mountains) then a very traditional building design might serve eg as with Moroccan houses.